A study was conducted to determine if the chicken ovary deposits the pesticide, lindane, into preovulatory egg yolks in a similar daily pattern as previously reported utilizing the antibiotics, ampicillin or oxytetracycline (Donoghue et al., 1996). Our laboratory has proposed that a variety of drugs or contaminants are deposited into preovulatory yolks in a "universal" pattern and this information has been used to model the pattern of residues contained in laid eggs (Donoghue et al., 1996). In two separate experiments, 16 hens were dosed with 3 mg/kg lindane orally approximately 1 h after oviposition (8 hens/experiment). Twenty-four hours after dosing, hens were euthanatized and the individual yolks were collected. Samples were prepared and assayed using a modified AOAC gas chromatography method. Results indicate the pattern of incorporation of lindane residues in developing yolks is similar to the previous pattern obtained for either ampicillin or oxytetracycline. These data confirm the possibility that diverse chemical compounds may be incorporated into preovulatory yolks in a similar pattern supporting a key component of our model that predicts the pattern of incurred residues in laid eggs for a variety of drugs or contaminants.